Vitamin D supplementation might decrease diabetes threat for the greater than 10 million adults with prediabetes.
A overview of scientific trials has discovered that increased vitamin D consumption was related to a 15 % decreased probability for growing sort 2 diabetes in adults with prediabetes. The overview was printed on February 7, 2023, in Annals of Inside Drugs.
Vitamin D is a fat-soluble vitamin obtainable in or added to some meals, as a complement, or produced by the physique when ultraviolet rays from daylight strike the pores and skin. Vitamin D has many features within the physique, together with a task in insulin secretion and glucose metabolism. Observational studies have found an association between having a low level of vitamin D in the blood and high risk for developing diabetes.
Researchers from Tufts Medical Center conducted a systematic review and meta-analysis of three clinical trials comparing vitamin D supplement impacts on diabetes risk. The authors found that over a three-year follow-up period, new-onset diabetes occurred in 22.7 percent of adults who received vitamin D and 25 percent of those who received placebo, which is a 15 percent relative reduction in risk. According to the authors, extrapolating their findings to the more than 374 million adults worldwide who have prediabetes suggests that inexpensive vitamin D supplementation could delay the development of diabetes in more than 10 million people.
In an accompanying editorial, authors from University College Dublin and Food Safety Authority of Ireland, highlight that previous data have demonstrated significant adverse effects for high vitamin D intake. They argue that professional societies promoting vitamin D therapy have an obligation to warn physicians about both required vitamin D intake and safe limits. They advise that this very-high-dose vitamin D therapy might prevent type 2 diabetes in some patients but may also cause harm.
“Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials” by Anastassios G. Pittas, MD, MS, Tetsuya Kawahara, MD, PhD, Rolf Jorde, MD, PhD, Bess Dawson-Hughes, MD, Ellen M. Vickery, MS, Edith Angellotti, MD, Jason Nelson, MPH, Thomas A. Trikalinos, MD and Ethan M. Balk, MD, MPH, 7 February 2023, Annals of Internal Medicine.
“Preventing Type 2 Diabetes With Vitamin D: Therapy Versus Supplementation” by Malachi J. McKenna, MD and Mary A.T. Flynn, PhD, RD, 7 February 2023, Annals of Internal Medicine.